5-Fluorouracil (5-FU)

5-Fluorouracil (5-FU)

Product Description

5-Fluorouracil, a pyrimydine analogue, is an antineoplastic agent that acts as an antimetabolite to uracil. After intra-cellular conversion to the active deoxynucleotide, it interferes with the synthesis of DNA by blocking the conver-sion of deoxyuridylic acid to thymidylic acid by the cellular enzyme thymidylate synthetase.

Basic info

• CAS number 51-21-8
• Molecular weight C₄H₃FN₂O₂ = 130.1
• Assay >98 %
• Loss on drying < 0.5 %

Technical

Storage condition

• Store at 2-8 °C
• Soluble in water (10 g/l)
• Loss on drying < 0.5%

Hazard statements

• H301 - Toxic if swallowed
• H312 - Harmful in contact with skin
• H332 - Harmful if inhaled
• H351 - Suspected of causing cancer
• H361 - Suspected of damaging fertility or the unborn child

Precautionary statements

• P201 - Obtain special instructions before use
• P281 - Use personal protective equipment as required
• P301 - IF SWALLOWED:
• P308 - IF exposed or concerned:
• P310 - Immediately call a POISON CENTER or doctor/physician
• P313 - Get medical advice/attention